gzhaa.blogg.se - Ns2 disease

These newly synthesized ssDNA can eitherĪ) be converted to dsDNA and serve as a template for transcription/replicationī) be encapsidated to form new virions that are released by cell lysis.

Individual ssDNA genomes are excised from replication concatemers by a process called junction resolution.

Replication occurs through rolling-hairpin mechanism, with NS1 endonuclease binding covalently to the 5' genomic end.

dsDNA transcription gives rise to viral mRNAs when host cell enters S phase and translated to produce viral proteins.

The ssDNA is converted into dsDNA by cellular proteins.

The viral ssDNA genome penetrates into the nucleus.

Microtubular transport of the virion toward the nucleus.

The virion penetrates into the cytoplasm via permeabilization of host endosomal membrane.

Attachement to host receptors initiates clathrin-mediated endocytosis of the virion into the host cell.

Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), Helsinki, Finland. Host proteins transcribe the genomes into mRNAs.Īlternative mRNAs splicing allows expression of six different mRNAs. Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKK and TBK1 functions. The genome is replicated through rolling-hairpin mechanism. ORFs for both the structural and non-structural proteins are located on the same DNA strand. Equal amount of positive and negative strands are encapsidated, although the percentage of particles encapsidating the positive strand can be lower depending on the host cell. Linear, ssDNA genome (-) of about 4.8kb in size. The capsid consists of 60 copies of CP protein. Non-enveloped, round, T=1 icosahedral symmetry, 18-26 nm in diameter.